Nadja Uhl, born May 23, 1972, in Stralsund, studied acting at Leipzig's Hochschule "Felix Mendelssohn-Bartholdy" from 1990 to 1994. During that time, she already made her movie debut in small supporting part in "Der grüne Heinrich" ("The Green Henry", 1993). After her graduation, she became a cast member of Potsdam's Hans Otto theatre where she starred in productions of classic plays such as "Faust" or "Twelfth Night". Uhl left Hans Otto theatre in 1995 to pursue her acting career as a freelance actor, mainly in film and TV productions. At first, Uhl mainly starred in TV productions such as Peter Patzak's thriller "Ein mörderisches Erbe" (1998), or in "Mein ist die Rache" (1998) alongside Ulrich Noethen.

Uhl made her breakthrough performance in 2000 as a quiet rebel in Volker Schlöndorff's terrorist drama "Die Stille nach dem Schuß" ("The Legends of Rita"). She also won a Silver Bear as Best actress at the 2000 Berlinale for her performance which paved her way to more top-class movie parts. In the process, the part of an unconventional woman who is at the same time rebellious yet sensitive became her signature role. Thus, she played a former squatter in Gregor Schnitzler's highly praised drama "Was tun, wenn"s brennt" ("What to Do in Case of Fire"), portrayed a young woman who falls in love with a contract killer (played by Joachim Król) in the thriller "Lautlos" ("Soundless", 2004), and played a quick-witted Berliner who is looking for love in Andreas Dresen's box office hit "Sommer vorm Balkon" ("Summer in Berlin"). In 2008, she played a leading role in Doris Dörrie's award-winning melodrama "Kirschblüten" (Cherry Blossoms – Hanami), that is featured in the competition of the 2008 Berlinale.

The same year, she was cast in a completely different role in Uli Edel's controversial "Der Baader Meinhof Komplex". In the film, Uhl portrays terrorist Brigitte Mohnhaupt. Just a few months later, she basically switched sides for "Mogadischu", a dramatization of the 1977 hijacking of the Lufthansa plane Landshut: Now Uhl played stewardess Gabriele Dillmann, who is taken hostage by terrorists.

In 2009, Nadja Uhl starred in two acclaimed feature films, the drama "So glücklich war ich noch nie" and the comedy "Männerherzen". For the latter, she was nominated for the 2010 German Film Award. The same year, she was also nominated for the German Television Award for her performance in the crime drama "Der Tote im Spreewald". Uhl went on to play a mother relocating with her family to the jungle in "Dschungelkind" (2011),and also starred in "Männerherzen ... und die ganz ganz große Liebe" (2011), the sequel to the 2009 box office hit.