Lucas Gregorowicz was born in London in 1976 but mainly grew up in Bochum where he attended Westfälische Schauspielschule from 1996 to 2000. From 1997 on, he was a guest cast member at Schauspielhaus Bochum where he performed in Leander Haußmann's 1999 production of Shakespeares "Much Ado about Nothing". After several appearances in TV series such as "Motorradcops", "Die Wache", and "Adelheid und ihre Mörder", Gregorowicz made his movie debut alongside Moritz Bleibtreu in Christian Zübert's cannabis comedy "Lammbock". He then starred in Fatih Akin's "Solino", in Vivian Naefe's "So schnell du kannst", and in Sönke Wortmann's "Das Wunder von Bern" ("The Miracle of Bern"). In "Cattolica", directed by Rudolph Jula, Gregorowicz played the hedonist Stefan whose life is turned upside down when he meets a stranger.

In the following years, Gregorowicz was regularly seen on TV and starred, for instance, as Jona in the ARD series "4 gegen Z" (2005 to 2007). Since his last role in movie in the drama "Sugar Orange" (2004), it took him until 2008 to return to the big screen in a leading role: In "Hardcover", Gregorowicz played a wirter, who turns to the milieu of small-time criminals to find inspiration for his next novel. The film was again directed by Christian Zübert. Also in 2008, he played the henchman of a Hamburg drug lord in "Chiko". Following his memorable supporting turn as a waiter cum musician in Fatih Akin' s comedy "Soul Kitchen" (2009), he joined the ensemble of Lars Jessen's comedy "Hochzeitspolka" (2010).

Gregorowicz next starred in a string of TV productions, including the British miniseries "The Promise" (2011), the popular WWII drama "Unsere Mütter, unsere Väter" ("Generation War", 2013), the comedy "Nina sieht es …!!!" (2011) and the biopic "Clara Immerwahr" (2014). In 2014, Gregorowicz starred as a crafty doctor in the comedy series "Schmidt – Chaos auf Rezept". After playing a German lobbyist in the Austrian satirical series "Vorstadtweiber" (2015), Lucas Gregorowicz was cast as the new lead for a spin-off of the popular "Polizeiruf 110" series.

He returned to the big screen as one of the leads of the caper comedy "Schrotten!" ("Scrappin'", 2016), in which he plays a shady insurance salesman who inherits a junkyard from his father and ends up planning a heist with his unlike brother. Also in 2016, Gregorowicz played a hitman in two episodes of the TV series "Stralsund" and starred along with Lars Eidinger and Rainer Bock in the miniseries "SS-GB" (2017), which is set in 1941 in a fictitious London occupied by the Nazis.

Lucas Gregorowicz next reprised his role from the cult comedy "Lammbock" ("Lammbock – Shit Happens") for the sequel "Lommbock" before starring in "Sommerfest", an adaptation of the eponymous novel by Frank Goosen. In the film he played a theatre actor who meets old friends and his childhood love during a visit to his home town Bochum.  

For television he wrote the thriller "Passagier 23 - Verschwunden auf hoher See" ("Passenger 23", 2018), with Gregorowicz as an unstable police psychologist who is supposed to interview a traumatized girl on a cruise ship. Lucas Gregorowicz played an important role in the first season of the award-winning series "Der Pass" ("Pagan Peak", 2018-2019): a muckraker who gets into a momentous contact with a serial killer. In addition, he continued to play the role of the Chief Inspector in the selected episodes of the crime series "Polizeiruf 110".  

On the big screen he was seen in the action comedy "Der letzte Bulle" (2019) as an old buddy of the title character, and in a supporting role in the neo-noir thriller "Man from Beirut" (2019). The start of Oskar Roehler's Fassbinder film biography "Enfant Terrible" followed in october 2020, with Gregorowicz impersonating the late actor Ulli Lommel.