Jasmin Schwiers was born on August 11, 1982, in Eupen, Belgium, and grew up in the country's German-speaking community. She discovered acting at the age of ten through a children's theater production, where an audience member recognized her talent and connected her with a well-known talent agency. 

Schwiers made her television debut in 1994 with a guest role in the crime series "Die Wache," followed by supporting roles in TV productions such as "School's Out" (1997). Her breakthrough came in the comedy series "Ritas Welt," in which she played the daughter of the title character from 1999 to 2001. For her performance in Wolfgang Limmer's "Heimliche Küsse – Verliebt in ein Sex-Symbol" (2000), portraying the paralyzed sister of the main character (Alexandra Neldel), Schwiers shared the Günter-Strack Television Award with Neldel. 

She made her feature film debut in the 1999 comedy "Alles Bob" ("All About Bob") and the following year appeared alongside Daniel Brühl in the critically and commercially successful teen film "Schule" ("No More School," 2000). She went on to take roles in a variety of films, including Joseph Vilsmaier's World War II drama "Leo und Claire" ("Leo and Claire," 2001), as the daughter of a Jewish family, and Robert Schwentke's thriller "Tattoo" (2001), as a commissioner's daughter. 

In the TV teen comedy "Endlich Sex!" (2004), she played the lead role of a 17-year-old eager to have her first sexual experience, while in the TV drama "Die Konferenz" (2004), she portrayed a student allegedly assaulted by a classmate. In the following years, she appeared in numerous TV films and guest roles. Her first lead role in a feature film came with Leander Haußmann's comedy about military service in the former GDR, "NVA" (2005). That same year, she was honored with the Lilli-Palmer Memorial Camera at the Goldene Kamera awards. 

Other lead film roles included playing the wife of the main character in "Lauf um Dein Leben – Vom Junkie zum Ironman" ("Run For Your Life!," 2008), a small-town resident in the coming-of-age film "Little Paris" (2008), and a partner-in-crime alongside Otto Waalkes in his comedy "Otto's Eleven" (2010). She also appeared in supporting roles in the psychological thriller "Kleine Morde" ("Little Murders," 2012) and the comedy "Männerhort" (2014). 

Television remained Schwiers' primary focus. She played lead roles in comedies such as "Machen wir's auf Finnisch" (2008) and "Mein Flaschengeist und ich" (2009), as well as significant roles in TV films including "Und alle haben geschwiegen" (2012) and "Heiraten ist nichts für Feiglinge" (2015), among others. 

From 2015 onwards, Schwiers held a regular lead role in the crime series "Die Füchsin," whose episodes were produced sporadically over the years. In 2021, she added another regular TV role with "Klara Sonntag," portraying the superior of the main character. 

In addition to numerous TV appearances, Schwiers occasionally appeared in films. In the divorce comedy "Schatz, nimm Du sie!" ("It's Your Turn, Honey!," DE/FR 2017), she played a close friend of the central ex-couple. In the sketch-style comedy "Die Geschichte der Menschheit – leicht gekürzt" (2022), she took on nine different roles, including a Neanderthal woman. Michael Herbig cast her in a lead role as a Wild West adventurer in his Western parody "Das Kanu des Manitu" ("The Canoe of Manitou," 2025).