Margarita Breitkreiz was born in Omsk on January 7 1980. In 1992, her family relocated to Germany, and from 2002 until 2006, she studied acting at the Hochschule für Schauspielkunst 'Ernst Busch' in Berlin.

During her training, she already appeared in stage productions at the bat-Studiotheater, at the Schloss Neuhardenberg and at the Volksbühne. Moreover, she made her first TV appearances, guest-starring in shows like "Abschnitt 40" and "Die Rosenheim-Cops".  In 2004, she was the female lead opposite Axel Prahl in the made-for-TV drama "Der Grenzer und das Mädchen".

After her graduation in 2006, Margarita Breitkreiz continued to star in numerous TV productions, while also pursuing her stage career at the Volksbühne in Berlin, where she acted in productions of "Berlin Alexanderplatz" (2008; Director: Frank Castorf), "Der Kaufmann von Berlin" (2010; Director: Castorf), "Der eingebildete Kranke" (2012; Director: Martin Wuttke), "Kaputt" (2014; Director: Castorf) and "Exodus" (2016; Director: Sebastian Klink).

In Michael Koch's drama "Marija", which premiered at the 2016 Berlin IFF, Breitkreiz starred in the role of an Ukranian woman whose life in Germany starts to unravel after she loses her job. Her performance garnered Breitkreiz the Prix Mademoiselle Ladubay for Best Female Aco at the Festival Premiers Plans in Angers.

She played another leading role in the award-winning Austrian comedy "Kaviar" ("Caviar", (2019), as a Russian interpreter who wants to steal from a decadent oligarch in Vienna. Sobo Swobodnik cast her as his alter ego in the lead role of the semi-documentary "Klassenkampf" ("Class Struggle", 2020). On television, Breitkreiz appeared in guest roles in the series "In aller Freundschaft", "Der Usedom-Krimi" and "SCHULD nach Ferdinand von Schirach" ("Shades of Guilt").

Breitkreiz's main field of activity remained the theater, especially as a member of the ensemble at the Volksbühne am Rosa-Luxemburg-Platz. In 2023, as a member of the artist collective ClaudeHilde, she developed the social sculpture "Artist at Work" together with Julia Thurnau.

She also played a leading role in Sobo Swobodnik's "Geschlechterkampf - Das Ende des Patriarchats", for which she co-wrote the script.