Hannes Wegener, born September 2, 1980, in Potsdam, already was on camera for the first time as a teenager: In Andreas Kleinert's film "Verlorene Landschaft" ("Lost Landscape", 1992) and in the children's film "Olli in der Unterwelt" (1993), he played minor supporting parts. Wegener attended actor's training at HFF Potsdam and graduated in 2006. During his time at HFF, he had already starred in minor roles in TV productions, for instance, in "Pfarrer Braun – ein verhexter Fall" (2004) or in "Eine Prinzessin zum Verlieben" (2005).

Besides his numerous TV appearances and occasional theatre performances, Hannes Wegener was seen on the movie screen in the role of the RAF terrorist Willi-Peter Stoll in Uli Edel's drama "Der Baader Meinhof Komplex" ("The Baader Meinhof Complex", 2008) and in Matthias Glasner's psychological drama "This Is Love" (2009). Wegener played his first leading role on the movie screen in Jonas Grosch's film "Résiste – Aufstand der Praktikanten" ("Resist! Intern Rebellion", 2009). In the satirical romantic comedy, he plays a conformist yuppie who falls in love with a leftist protest activist of all people. In 2009, Wegener also landed a role in Tom Tykwer's Berlin-set ensemble film "Drei" ("Three") that opens in cinemas in 2010.

In the following years, Wegener predominantly appeared in supporting roles in TV and film productions. He played an East-German youth counsellor in "Westwind" (2011) and a canny auditor in the crime drama "Ein mörderisches Geschäft" (2011). In 2011, he was cast by director Eike Besuden for the title role in the semi-documentary drama "Gibsy - Die Geschichte des Boxers Johann Rukeli Trollmann". In the film, which was released in January 2013, Wegener plays the legendary Sinto-German boxer, who was murdered by the Nazis in 1944.