Nicole Weegmann was born in Karlsruhe in 1966. She studied at the Universita italiana per Stranieri in Perugia and subsequently worked as a photo assistant at Cinecittà studio lot in Rome. Back in Germany, she trained as a photographer at the Lette school in Berlin, and later majored in audio-visual arts at the Gerrit Rietveld art academy in Amsterdam. Weegman then enrolled at the film academy in Ludwigsburg, and already her first short "Kreisel Macher Brumm" (1992) won several awards.

In 2000, she made her feature film debut with the TV production "Wolfsheim", a drama about three former classmates whose attempt to free a jailed friend leads to crime and violence. She then directed the "Tatort" episode "Romeo und Julia" (2003) and the youth drama "Rabenkinder" (2003). Her fourth made-for-TV feature film "Ihr könnt Euch niemals sicher sein" (2008), a drama about a 17-year-old who is suspected of being a potential gunman running amok, got rave reviews and won multiple awards, including the 2009 Grimme Award. In 2010, Weegman"s first cinema release "Schenk mir Dein Herz" premiered at the Hamburg Film Festival. The tragicomedy about two musicians who form a Jazz band in a rehab hospital opened in German theatres in spring 2011.