Marc Hosemann was born in Hamburg in 1970. He worked as a mail man after finishing school before attending Hamburg"s Hochschule für Musik und darstellende Kunst and graduating from the École international de Thèatre Jacques Lecog in Paris. During this time he already played minor parts in Janek Rieke’s short films "Die hirnlose Frau" and "Neulich am Deich" before making his stage debut in Brecht"s "Mutter Courage" at Hamburg"s Thalia Theater. He then played in Falk Richter"s two-person-play "Kult" at the Schauspielhaus Düsseldorf and from 1998 on alongside Bibiana Beglau in Thomas Ostermaier"s "Disco Pigs", which was performed in Hamburg and Berlin, alternately.

In 1996, Hosemann was seen on television for the first time and made appearances in TV series such as "Alles außer Mord", "Sperling" and "SOKO 5113". Following some supporting parts in movies like "Härtetest" and "Kurz und schmerzlos", and the part of a sensitive derelict in Detlev Buck"s "Liebe Deine Nächste", Hosemann played his first leading part in Rainer Kaufmann"s thriller "Long Hello and Short Goodbye" alongside Nicolette Krebitz.

He then performed in various German and international TV productions and movies, like Adan Rudolphs" "Investigating Sex" (2001). Ralf Huettner"s romantic comedy "Reine Nebensache" saw Hosemann in another leading role. Aside from his film work, Hosemann still performs on stage. Since 2002, he is a cast member of the Berliner Volksbühne, where he performed in Frank Castorf"s production of "Berlin Alexanderplatz".