Anna Maria Mühe, born 1985 in Berlin, is the daughter of Ulrich Mühe and Jenny Gröllmann. She met director Maria von Heland in a bar in Berlin and made her movie debut in Heland's drama "Große Mädchen weinen nicht" ("Big Girls Don't Cry") – a performance that won her an award at the Las Palmas film festival. In 2003, Mühe played a school girl whose unrestricted love life causes a tragedy in Achim von Borries' drama "Was nützt die Liebe in Gedanken" ("Love in Thoughts"). Again, Mühe won an award for her performance, this time the award for "Best actress" at the 2004 Copenhagen film festival.

Mühe then starred in several TV productions and made a striking performance as a daughter of sect followers who tries to break free from her rigid surroundings in Jobst Oetzmann's "Delphinsommer". Mühe was also highly praised for her part in Maris Pfeiffer's "Meine böse Freundin". She then returned to the big screen in Bülent Akinci's "Der Lebensversicherer" ("Running On Empty") and Ed Herzog's "Schwesterherz". This role not only garnered her the newcomer award at the Filmkunstfest Mecklenburg-Vorpommern, but also a nomination for Best Actress at the German Film Prize.

Following supporting roles in Til Schweiger's "1 ½ Ritter – Auf der Suche nach der hinreißenden Herzelinde" (2008), Julie Delpy's "Die Gräfin" (2009) and Alain Gsponer's "Lila, Lila" (2009), Mühe played the lead in two productions in 2009/2010: In "Live Stream" she portrayed a suicidal student, and in Hans W. Geissendörfer's "In der Welt habt ihr Angst" (to be released in early 2011) she plays a music student who follows her lover into heroin addiction.